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Under conditions of metabolic stress, such as hypoxia, glucose deprivation, and low serum, ACSS2 enzyme can promote malignant cell growth and survival in some solid tumors through the production of acetyl-CoA, which is further incorporated into metabolic pathways or acts as an epigenetic modulator in the activation of protein acetylation [74]

Tumor suppression in early carcinogenesis In early tumorigenesis, autophagy preserves cellular homeostasis by limiting oxidative stress, clearing damaged organelles, and regulating inflammation

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