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Molecular mechanisms and signaling pathways mediated by EVs Energy metabolism and mitochondrial function regulation Mitochondrial dysfunction, manifested as impaired oxidative phosphorylation [104] , disrupted energy metabolism [105] , defective mitophagy [106] , and mutations in mitochondrial DNA [107] , is a core pathological feature of AD

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7 Limitations of buckwheat research and future perspectives Despite growing evidence supporting the health benefits of buckwheat, several limitations persist in the current research that warrant careful consideration

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