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Additionally, CBC reduced LPS-induced activation of murine peritoneal macrophages in vitro, an effect likely contributing to its in vivo anti-inflammatory activity [168]

In summary, evidence from studies indicates that the endocannabinoid system plays a central role in modulating the HPA axis, functioning as an inhibitory mechanism that maintains basal stability and limits exaggerated stress responses

USA 107 , 1775717762 (2010)

Microb Pathog (2018) 121:2628

Consequently, intracellular GSH depletion increases the free copper pool, promotes protein oligomerization, and heightens sensitivity to copper-mediated cell death [110]