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Supplementary material For supplementary material accompanying this paper visit Acknowledgements The authors would like to thank the Clinical Research Development Unit of Baqiyatallah Hospital, for all their support and guidance during carrying out this study

Both, superoxide and hydroperoxyl radicals oxidize AscH to ascorbyl radicals (Asc )

H 2 O 2, which is not converted to H 2 O, can form reactive hydroxyl radicals (OH) when reacted with transition metal ions (Fe 2++ /Cu)

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Its Innovative Science and Technology Approaches for New Drugs (ISTAND) pilot program is explicitly considering complex in vitro models like OoCs, with a liver-on-chip for DILI being the first OoC accepted into the program for evaluation (222)