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The most useful drugs are phenytoin (or fosphenytoin, which is not available in Spain) and lidocaine (class IV, grade of recommendation C for both drugs).64,65 Treatment of trigeminal neuralgia with concomitant continuous pain As mentioned previously, some patients may present a dull background pain between paroxysms, potentially due to a combination of structural nerve damage secondary to prolonged neurovascular compression on the one hand and central sensitisation phenomena on the other

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and bone morphogenic protein-12 (BMP-12) and TGF1 [65])