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As diabetes progresses, persistent hyperglycemia increases the levels of inflammatory factors, advanced glycation end products (AGEs), reactive oxygen species (ROS), free fatty acids (FFAs), triacylglycerol, and diacylglycerol in the heart, retina, kidneys, and nervous system (912)

Similarly, the activity of the selenium-containing glutathione peroxidase enzyme, responsible for speeding up the reaction between glutathione and free radicals (such as hydrogen peroxide) will be negatively affected if dietary selenium is low and enhanced when selenium is high

doi: 10.3389/fcvm.2022.1109445 Received 27 November 2022 Accepted 28 December 2022 Published 16 January 2023 Volume 9 - 2022 Edited by Liming Yu, The University of Texas Health Science Center at San Antonio, United States Reviewed by Yuanli Chen, Hefei University of Technology, China

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