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When the liver is damaged, HSCs are activated, changing from a static vitamin A-rich state to a myofibroblast-like phenotype

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65% of iCCAs) are enriched in immunosuppressive M2-like macrophages and hyperactivated CD4 + regulatory T cells that induce a suppressive local immune milieu 119 , which is associated with FGFR2 fusions, mutations in IDH1/2 and BAP1 and co-occurrence of KRAS / TP53 mutations