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6.2.2 DNA damage-dominant phenotype (oxidative genotoxic stress) This phenotype is characterised by high levels of oxidative DNA damage, as reflected by biomarkers such as 8-OHdG and an increased DNA fragmentation index (157)

The much larger, headline-grabbing numbers associated with cagrilintide in the press figures in the low-to-mid 20% range come from Phase 3 trials of CagriSema , the combination with semaglutide, and are company-reported topline results, not standalone-cagrilintide data and not the peer-reviewed Phase 2 result cited above