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Nitric oxide and the cerebral vascular function

Moreover, mitochondrial damage elevates ROS levels (380), which can in turn damage mtDNA and proteins that may be involved in the electron transport chain (ETC), resulting in lowered ATP production and decreased energy levels (381)

There are no controlled data in human pregnancy

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Although the precise mechanism by which VPA induces hyperammonaemia is not fully understood, it is widely accepted that VPA disrupts normal ammonia metabolism by directly inhibiting carbamoylphosphate synthetase, a critical enzyme in the urea cycle, and indirectly depleting carnitine