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Figure 2 Potential of TNF- Inhibitors in COVID-19 Since TNF- production plays a vital role in these processes, inhibiting TNF- may be an effective strategy in attenuating both SARS-CoV2 infection and the resulting organ damage (69)

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The mature adipocytes secrete BMP4 that triggers preadipocyte differentiation by inducing the separation of Wnt1 inducible-signaling pathway protein 2 (WISP2) and zinc finger protein 423 (ZNF423), allowing ZNF423 to translocate into the nucleus and activate peroxisome proliferator-activated receptors (PPAR) and downstream cascade including CCAAT/enhancer-binding proteins (C/EBP), , and [41, 42] ( Figure 1 )