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The following water-soluble vitamins have set ULs, as they can cause adverse side effects when taken in high doses: Vitamin C

If you do not produce enough intrinsic factor, you may become deficient

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(read about COMT)[ref] Not all studies agree, and some studies show that the MTHFR C677T variant has little to no impact on depression risk

doi: 10.1007/BF01537272

or the availability of the device is in the best interest of patients