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Duloxetine reduced the brain response to cold-induced pain in S2/insula (Shidahara et al., 2019 and Nagasaka et al., 2017), and reduction in CIPN pain from neurofeedback was associated with a reduction in insula activity at rest (Prinsloo et al., 2017) as well as a reduction in resting power (1345 Hz) in the bilateral parietal cortices and midline regions (including the ACC and DMN

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