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Glutathione conjugates experience removal of the -glutamyl moiety via either GGT on the renal brush-border membrane or through other GGT-expressing cells such as the vasculature, which is followed by the removal of Gly units via extracellular dipeptidases (Figure 2)

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In addition, we found that NLRP3 inflammasome-derived IL-1 secretion by SARS-CoV-2-exposed monocytes in vitro was partially dependent on lipid peroxidation

The repression of the major porins OmpF/C in the outer membrane complements the Cus system, as mentioned (Lok et al., 2008

doi: 10.1021/jf1033202 126

Activity of DNMTs The induction of epigenetic alterations, particularly aberrant DNA methylation, is strongly associated with chronic inflammation and various human diseases, including cancer, neurodegenerative diseases and metabolic disorders