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For example, asymptomatic stones discovered during diagnostic imaging may not be treated, but an acute symptomatic kidney stone demands an intervention, even if only hydration and painkillers for a small stone (Curhan 2012

and activation of synaptogenic intracellular signaling, including mammalian target of rapamycin complex (TORC1) (Freo and Ori, 2002b, 2003

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