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In Addition, many other GWAS also confirmed a connection between liver disease and mARC1 [98,99,100]

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So I think anybody can get Alzheimer's disease with any genotype if there's enough insulin resistance, if there's basically enough difficulty in getting glucose through pyruvate dehydrogenase and into the Krebs cycle

While numerous studies have demonstrated the antidepressant and neuroprotective effects of exercise and polyphenols individually, their combined effects remain underexplored, particularly in clinical populations