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Its a small-molecule compound built to inhibit an enzyme called NNMT (nicotinamide N-methyltransferase), which has a role in how fat cells manage metabolism and energy expenditure

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Retatrutide produced an average weight reduction of 24.2% at the 12 mg dose after 48 weeks in its Phase 2 obesity trial, according to Jastreboff and colleagues (NEJM, 2023

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For those practicing intermittent fasting , administration at the end of the fasting window, just before breaking the fast, provides a strong lipolytic signal during an already optimized metabolic state