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In Transcobalamin-Oleodin animal models, Vit B12 deficiency induced dopaminergic caspase-2 mediated cell-death in substantia Nigra (Orozco-Barrios et al

American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity

Li X, Wang Y, Yang Q, Song L, Kang L, Hu Z, et al

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The absence of serious adverse events, treatment-related withdrawals, IGF-1 elevation, glucose metabolism impairment, or immunogenic responses represents a favorable safety foundation