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Precisely, superoxide anion and hydrogen peroxide have been reported to act as mitogens, thereby promoting the rate of DNA replication and cell proliferation in a variety of cultured cells.9, 10 Nonetheless, in excess amounts, oxygen-derived radicals are very harmful to living organisms

At present, a variety of studies have found that DNMT inhibitors or demethylases play an important role in the cure of diseases, including diabetic nephropathy, chronic kidney disease, renal cell carcinoma, prostate cancer and bladder cancer (Table I) (160,198,256-260)

The ATP-depleting futile 5-oxoproline cycle may also play a role in the energy depletions that occur in other acetaminophen-related toxic syndromes.

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