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In INS-1 pancreatic beta cells, GLP-1 treatment reduced the oxidative damage caused by tert-butyl hydroperoxide

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Studies have shown that hyperglycemia-induced mitochondrial fragmentation, mediated by an imbalance in fission and fusion proteins such as Drp1 and OPA1, contributes to mitochondrial dysfunction and impairs ATP synthesis in retinal capillary and Mller cells (16)

The pHrate profile of the conversion of reduced SetCys peptide 2 into cysteinyl peptide 3 shows a maximum at pH 6.0 0.04 and two inflexion points at pH 4.8 and 7.3, which likely correspond to the pK a s of the SetCys selenol and ammonium groups, respectively

Macroautophagy starts with a precursor structure, known as the phagophore, that eventually transforms into an autophagosome