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Those with pre-existing GI conditions, including gastroparesis, inflammatory bowel disease, or chronic pancreatitis, should avoid retatrutide entirely

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In fact, BH4 deficiency impaired the expression of the PGC-1-dependent genes that regulate mitochondrial biogenesis, mtDNA transcription, and mRNA translation [111], suggesting a prominent role of BH4 metabolism in mitochondrial biogenesis

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Overdoses manifest themselves in the form of acne or gastrointestinal complaints such as diarrhea or nausea