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Mutant huntingtin impairs immune cell migration in Huntington disease

Consistent with this, we observed transcriptional alterations in cholesterol-associated genes and enrichment of cholesteryl esters in OVCA ascites, supporting a role for sterol metabolism in the ascites response

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Sclera is a dense (400-1000 m thick) connective-like tissue mainly composed of collagen and elastin fiber and populated with ECM-producing fibroblasts

Research has shown that phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first reaction in the serine synthesis pathway, was highly upregulated in metastatic breast cancer and was correlated to short patient survival times [135, 136]