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173 TakakuraY.OkaN.KajiwaraH.TsunashimaM.UsamiS.TsukamotoH.et al (2010)

Although reduced protein stability promotes amyloid formation, it alone cannot fully explain disease onset, as pathology is also influenced by external factors

Wu, D., Xu, H., Chen, J., & Zhang, L

The relative abundance of tim influences cry stability, as tim competitively inhibits cry degradation, indicating that jet targets these proteins sequentially depending on their relative affinities (Peschel et al., 2009)

Chemical Society Reviews

This theory has been augmented by several studies that demonstrated increased markers of oxidative stress (by-products of non-enzymatic lipid peroxidation) in children suffering from konzo as well as documentation of deficiencies in micronutrients which are required to maintain effective antioxidant response in konzo-prone populations 18,19