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In CD has been widely reported an increased expression of pore-forming proteins such as occludin and claudin-2, together with a decrease of pore-sealing proteins such as claudin-3 and -4 and ZO-1 (84, 262264)

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There are four main types of multiple sclerosis defined according to the disease course: (i) clinically isolated syndrome, (ii) relapsing-remitting multiple sclerosis, (iii) secondary progressive multiple sclerosis, and (iv) primary progressive multiple sclerosis (for more information, visit the National Multiple Sclerosis Society website) (86)

doi: 10.1016/j.jprot.2011.06.015

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