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Conditions That May Necessitate Cortisone Injections: Osteoarthritis Rheumatoid arthritis Tendonitis Bursitis Rotator cuff injuries Tennis elbow (lateral epicondylitis) Carpal tunnel syndrome Plantar fasciitis Frozen shoulder (adhesive capsulitis) Lumbar radiculopathy Knee osteoarthritis (including meniscal tears) Other musculoskeletal conditions Signs Indicating You May Need Cortisone Injections: Persistent joint pain Swelling and inflammation Limited range of motion Tenderness at the injection site Recurrent or chronic musculoskeletal discomfort Diagnosed inflammatory conditions like arthritis How Cortisone Injections Work Cortisone injections function through the action of corticosteroids, which are synthetic versions of the bodys naturally occurring hormone, cortisol