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Tretinoin, by contrast, is the biologically active form of vitamin A

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This observation can be explained by the threshold effect of SDS concentration introduced by Manalastas, indicating that higher concentrations and longer exposure times do not necessarily translate into better outcomes, supported in our prior study, showing significant loss of mechanical properties, including GAG reduction, impaired collagen integrity, and altered ECM interactions after a gradual increase in SDS concentrations 36