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Patients with ALS develop weakness, muscle denervation, atrophy and progressive paralysis of all muscles (bulbar and respiratory), dysphagia (DAmico et al., 2013

Arsenic (As) is a ubiquitous metalloid displaying high toxicity [16], and inorganic arsenic (the most abundant species present in the environment) has been shown to mainly exist in one of two forms, arsenate [As(V)] and arsenite [As(III)], depending on redox potential (Eh) and pH in the environment [17, 18]

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With appropriate management, most patients experience significant improvement or full resolution within three to twelve months of surgery

Despite the certainty of ages significance, little effort appears to have been made to investigate how age and the aging process interact (Obeso et al., 2010