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These moieties are formed by the univalent reduction of oxygen in mitochondria, where the superoxide radical (O2-) is formed, followed by hydrogen peroxide (H2O2) and hydroxyl radical (OH) formation

PubMed Central, Yang, Quanhe, et al

Conversely, histone deacetylases (HDACs) are capable of removing acetyls from NRF2, thereby reducing its acetylation level and attenuating its transcriptional activity and stability