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This protection aids in maintaining skin integrity and appearance, contributing to a more vibrant and youthful complexion

Compared to healthy mice, DSS treatment caused a 12-fold increase in Il1b, a 29-fold increase in Il6, a three-fold rise in Tnf, and a six-fold rise in Nos2 mRNA levels

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For the FOXO4-DRI treatment group, 50 M FOXO4-DRI (MCE, HY-P4157) was added to the glucose-free DMEM (Gibco, Catalog #11966-025) medium, followed by 3 h of oxygen-glucose deprivation (OGD) treatment

The team also employed a more traditional fingerprint method the Tanimoto index that runs on a regular laptop