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Long-term stability of blood glutathione and cysteine in humans

However, it does not correct the underlying cystic fibrosis transmembrane conductance regulator defect, as shown by the lack of improvement in nasal transepithelial potential difference in cystic fibrosis transmembrane conductance regulator-deficient mice, indicating that epithelial ion transport remains impaired

Furthermore, the model confirmed the potent antioxidant capacity of DEC, as evidenced by reduced ROS levels and upregulated Nrf2 expression, suggesting effective dermal penetration and activation of endogenous protective mechanisms

Additionally, pairing TMZ with the anti-EGFR antibody nimotuzumab has shown potential for improving treatment effectiveness by targeting the EGFR mutation common in many GBM cases [69]

Iron metabolism plays a central role, as excessive intracellular iron promotes the Fenton reaction, generating lethal amounts of ROS that drive lipid peroxidation [4]

Bubak, M