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These dose levels resulted in systemic exposures approximately 0.11, 0.28, and 0.53 times, respectively, the exposure (AUClast) in humans at the recommended human dose of 80 mg

Peer review Peer review information Nature Communications thanks Ziqi Chen and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

IGF-1 Receptor Signalling: The PI3K-Akt-mTOR and MAPK Pathways Binding of IGF-1 LR3 to IGF-1R activates two interlocking cascades

This work was supported by VA-merit BX002086 (to P.D.), DK088902 (to A.B.S.) and BX002761 (to A.B.S.)

Wang Q, Jin F, Zhang J, Li Z, Yu D

The -subunits form the extracellular domain, while the -subunits include the transmembrane and intracellular regions, with the transmembrane portion anchoring the receptor to the cell membrane