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Modulatory Profile of Lethal Small Molecules The following lethal molecules were compared in a ten-point, two-fold dilution series modulatory profiling assay (high dose of dilution series in brackets): erastin (20 M), RSL3 (5 M), hydrogen peroxide (H 2 O 2 , 5 mM), artesunate (200 M), phenylarsine oxide (PAO, 1 M), taxol (0.5 M), suberoylanilide hydroxamic acid (SAHA, 50 M), trichostatin A (2.5 M), doxorubicin (2 M), fenretinide (50 M), staurosporine (STS, 0.5 M), brefeldin A (10 M), -lapachone (25 M), bortezomib (5 M), carbonyl cyanide m-chlorophenyl hydrazine (CCCP, 50 M), 2-methoxyestradiol (2-ME, 50 M), rotenone (2 M), helenaline (50 M), sulfasalazine (SAS, 1 mM) and phenethyl isothiocyanate (PEITC, 50 M)

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