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Canonical cleavage takes longer but selectivity improves linearly

[DOI] [PubMed] [Google Scholar] 314.Shi L., Xun W., Yue W., Zhang C., Ren Y., Shi L., Wang Q., Yang R., Lei F

J., Zheng, Y., Guan, Y

This is exemplified by foundational studies showing that CTLA-4 blockade efficacy in melanoma is microbiota-dependent: germ-free mice fail to respond to anti-CTLA-4, but oral supplementation with Bacteroides thetaiotaomicron or B

These modifications render the drugs inactive until they encounter specific conditions or biomarkers in vivo , at which point they are converted into active drug molecules

Quintana-Cabrera R, Quirin C, Glytsou C, Corrado M, Urbani A, Pellattiero A, et al