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Furthermore, the impact of endothelial cell senescence is not limited to the vascular system

Current Phase 3 trials (expected to report results in 2027) are exploring doses ranging from 4mg to 12mg weekly, with some protocols testing up to 16mg

Although DCE MRI can detect subtle changes in BBB permeability in well-controlled cohorts, differences in scanning equipment, parameters, and data processing between data collection sites can dilute these relatively small changes associated with AD and aging, which are typically one order of magnitude lower than the more robust changes of other disorders like ischemic stroke (Heye et al., 2014