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It has been suggested in the literature that to adequately address oxidative stress as a contributor to neurodegeneration, that we must also simultaneously address excitotoxicity (Li et al., 2013), but dietary micronutrients may offer an even better solution by reducing all three aspects of the neurotoxic triad, including neuroinflammation

Assessment of cold hyperalgesia Oxaliplatin (10 mg/kg) or vehicle (5% glucose solution) were intraperitoneally (i.p.) administered twice (days 1, 2) at a volume of 1 mL/kg of body weight

Importantly, placental and circulating miRNAs can modulate gene expression through epigenetic mechanisms and may alter key developmental pathways, including PPAR, mTOR, WNT, and insulin/IGF signaling, thereby influencing fetal growth patterns and long-term disease risk [41,43,44,45]

WM abnormalities typically result from dystrophic alterations of oligodendrocytes at the ultrastructural, genetic, epigenetic and molecular levels [162,163,164]

doi: 10.1038/nm1609 84 MolonBUgelSDel PozzoFSoldaniCZilioSAvellaDet al