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AdhTERT-E2F-1 can induce selective apoptosis of breast cancer cells through multiple mechanisms

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DNA synthesis and cell metabolism Intracellular conversion of vitamin B 12 to two active coenzymes, in mitochondria and adenosylcobalamin in the cytoplasm, is necessary for the homeostasis of methylmalonic acid and homocysteine, respectively

The TCA cycle in cancer cells is primarily fueled through glutaminolysis, which breaks glutamine down into intermediates that can be fed into the cycle

The clinical trial ran from February to December 2019

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