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1 Introduction Pathogens, autoimmune diseases, genetic disorders, and malignant tumors have been identified as triggers for life-threatening systemic inflammatory syndromes, characterized by excessive activation of immune cells and release of cytokines ( The inflammasome, an intracellular signaling complex of innate immune system, stimulated by the danger signals emitted from damaged cells and pathogens, resulting in the maturation and release of pro-inflammatory cytokines such as IL-1, IL-18 and IL-37, causing the activation of cysteine proteases including caspase-1/4/5/8/11 ( The primary liver cancer (PLC) ranks as the fourth common malignant tumors worldwide with a high mortality rate and its the leading cause of cancer-related death in China ( Cytokines play a pivotal role in liver diseases by impacting inflammatory responses, hepatocyte proliferation, liver fibrosis or cirrhosis

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