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107 Hyperglycemia also disrupts the structure and function of the bloodbrain barrier (BBB) by inducing oxidative stress and secondary inflammatory responses, impairing brain function and the biosynthesis of neurotransmitters

The extracellular degradation of GSH occurs on the surface of the cells that express the enzyme -glutamyl transpeptidase and the dipeptidases found in the external plasma membrane (1) (Figure 5)

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The abundance of the GSTs as an ensemble and their high catalytic efficiency indicate that release of NO occurs rapidly in normal tissues such that this influence must be considered in clarification of the tumor-killing effect of JS-K

Farbood Y, Rashno M, Ghaderi S, Khoshnam SE, Sarkaki A, Rashidi K, et al