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These findings indicate that thyroid dysfunction should be understood not only as an endocrine disorder but also as a neuropsychiatric condition

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Supporting evidence comes from a study comparing the amounts of FGF-21 and GDF-15 (as well-established biomarkers of mitochondrial disease), showing negligible diagnostic value in assessing mitochondrial dysfunction of PD patients (Davis et al., Therapeutic Approaches Recovering Physiological ATP Production by Targeting the ETC and Antioxidative Treatment Strategies Based on the close interconnectedness of ETC complex dysfunction and increased oxidative stress, most compounds trialled to date essentially influence both aspects of mitochondrial dyshomeostasis

Anselmo AC, Mitragotri S (2015) A review of clinical translation of inorganic nanoparticles

Consequently, the development of therapeutic agents that disrupt various aspects of Gln metabolism may represent a promising anticancer strategy ( Figure 2 )

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