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Best Practice Tip: Request a renal function test at the same time as the serum urate (and CRP) to allow for prompt urate-lowering treatment initiation, should a diagnosis of gout be confirmed

This effect can be explained by three mechanisms: First, the ability of PA to chelate iron, as Tinkov et al

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The requirement for this metabolic reprogramming in dendritic cell activity is evidenced by studies showing that inhibition of glycolysis with 2-deoxyglucose (2-DG) or knockdown of glycolytic inducers [e.g., HIF-1 and alpha enolase (ENO1)], impaired dendritic cell maturation, and subsequent T cell activation (78, 80, 82, 83)

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