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these include gastrointestinal problem 7 , sleep disorders 8 , immune system aberration 9 , neurotrophic factor dysregulation 10 , mitochondrial dysfunction 11 , and oxidative stress 12

PMID: 39586714

168 As reviewed by Brierley & Kelber, compounds like gingerol, menthol, and eugenol target TRP channels (e.g., TRPA1, TRPM8), which are responsible for pain and motility regulation in the GI tract

However, in hepatic and renal ischemiareperfusion, HIF-1 signaling plays a role in metabolic reprogramming and cytoprotective responses

10.1111/j.1365-313X.2004.02189.x 93 van den HeuvelR

10.1089/ars.2022.021 63 Escribano-LopezI.Diaz-MoralesN.Rovira-LlopisS.de MaraonA