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Accordingly, we infer that the efficacy of the SS shell critically depends on pathophysiological factors unique to the inflammatory intestinal microenvironment

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It is a frequent and life-threatening complication, particularly in Intensive Care Units (ICU), where it commonly arises in post-operative patients (24), hyperoxemia induced by mechanical ventilation or extracorporeal membrane oxygenation (25), systemic inflammation (26), and the metabolic effects of critical illness (27, 28), all of which may contribute to neuronal damage and cognitive dysfunction