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Description

Abstract Companion diagnostics (CDx) are powerful tests that can provide physicians with crucial biomarker information that can improve treatment outcomes by matching therapies to patients

Animals Adult female and male C57BL/6J mice (Harlan Laboratories), Cre/Lox mice lacking functional IGF-I receptors in orexin neurons (Floxed IGF-IR/Orexin Cre: Firoc mice), and channelrhodopsin (ChR)/Orexin-Cre mice (Ox-ChR mice) were used (3-6 months old