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On the basis of earlier studies in rabbits 29,31 , we developed a minimally invasive surgery for advanced keratoconus, inserting a thick, large-diameter BPCDX into an intrastromal pocket within the recipient cornea to counteract pathologic stromal thinning and normalize refraction by reshaping the central and peripheral cornea, without removing recipient tissue

doi: 10.1038/cmi.2017.133

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However, thrombosis usually occurs to some degree as a result of sclerotherapy