The mutant activity with ethidium bromide is highly reduced compared to the wild-type enzyme D201A - site-directed mutagenesis, G-site mutation, the mutant shows reduced activity compared to the wild-type enzyme D43N O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 naturally occuring mutation, the mutant is expressed at low levels causing GSTT1 deficiency D69A - site-directed mutagenesis, G-site mutation, the mutant shows reduced activity compared to the wild-type enzyme D69T - site-directed mutagenesis, G-site mutation, the mutant shows reduced activity compared to the wild-type enzyme D90N greatly decreased specific activity, shows no appreciable changes in Km for 1-chloro-2,4-dinitrobenzene and has similar circular dichroism spectra to that of wild type enzyme, the dimer-monomer equilibrium is shifted toward monomer D94N greatly decreased specific activity, shows no appreciable changes in Km for 1-chloro-2,4-dinitrobenzene and has similar circular dichroism spectra to that of wild type enzyme, the dimer-monomer equilibrium is shifted toward monomer delE155 O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 naturally occuring mutation, the polymorphic deletion of E155, from the deletion of AGG from the 5' splice donor site of exon 4, occurs at a low frequency in most populations and is strongly linked to K208 in Europeans and to E208 in Chinese individuals
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Some contain glutathione directly, while others provide the building blocks or nutrients that help your body produce and recycle it
