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Treatment with 5-amino-1mq upregulates proliferationrelated genes (Ki67, PCNA), promotes cell cycle progression, and improves cell fusion efficiency to form more multinucleated myotubes, achieving functional levels similar to those of young mice.Additionally, 5-amino-1mq inhibits muscle stem cell apoptosis, reduces oxidative stress damage, and maintains stemness

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The researchers noted that postmarket trial requirements and commitments are mandated by several regulatory authorities, including accelerated approval, the Pediatric Research Equity Act (PREA), and section 505(o)(3) of the FDA Amendments Act (FDAAA), and each mandates specific requirements

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