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Protonation of the ionizable components destabilizes the anionic vesicular membrane and facilitates nanoparticle disassembly, leading to the release of RNA to the cytosol, where RNA elicits its functions

By analyzing the properties of the targeting antibody and drug, we optimize the cleavage site and chemical structure to achieve efficient conjugation, specific cleavage, and precise drug release

Mater 12 (26), e2300890

Some progress has already been made in this direction

Millions of patients have used tirzepatide since 2022, providing extensive real-world safety experience beyond controlled trials

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