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Lactate enhances NMNAT1 lactylation to sustain nuclear NAD(+) salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditions

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We eventually succeeded in creating a model that had between 12- to 20- fold higher 5-OP levels, substantially higher folds than observed in mammalian system

Indeed, B 12 serum concentrations observed in different states of DPN may be only marginally reduced or even unchanged

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Li F, Lang F, Wang Y, Zhai C, Zhang C, Zhang L, et al