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I self inject into my thigh, I feel it but its ok, have been doing it for over a decade

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Potential regulators of the senescence-associated secretory phenotype during senescence and ageing

Therefore, experts generally do not advise giving goldenseal to infants and young children ( Animal studies suggest that berberine-containing supplements like goldenseal may result in lower birth weight and cause the uterus to contract, potentially increasing the risk of preterm birth ( Moreover, little is known about the safety of goldenseal while breastfeeding

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