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Direct causal links between specific Ca 2+ dynamics and macrophage fate outcomes, such as phagocytosis efficiency, intramacrophage bacterial killing, or apoptosis resistance, are largely absent in Klebsiella infection, with existing studies confined to mouse models and lacking human THP-1/PBMC validation, which is needed for clinical translation

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Instead, these companies prefer to use naturally occurring base structures, e.g., 5mC and 6 mA, to modify certain base(s), probably because of concerns about the safety of the metabolized unnatural residues that potentially might be incorporated into the genome

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