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Specifically, IRPs binding to IREs at the 5-UTR suppress translation of ferritin, FPN1, and amyloid precursor protein (APP), while IRP binding at the 3-UTR stabilizes mRNAs of TfR1 and DMT1, thereby promoting iron uptake under conditions of deficiency (Mai et al., 2023)

10.1016/j.toxrep.2014.09.016

Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons

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Third, there is marked heterogeneity in IF protocolsincluding variations in fasting duration, feeding windows, and participant characteristicscomplicating direct comparisons across studies and meta-analyses [15, 17,18,19]